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It has to do with focal actin kinases which act with GiActin in the extracellular matrix

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It functions through the activation of NADPH oxidase

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7,10 Environmental stressors also enhance glutamate transmission in limbic and cortical areas, which is implicated in dendritic remodeling, long-term potentiation, memory formation, and changes in brain volume (ie, atrophy)

doi: 10.1097/TP.0000000000000273 242 MerinoDSegundoDSMedinaJMRodrigoEAsensioEIrureJet al