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Moderate glutathione synthetase deficiency Patients with the moderate variant usually present in the neonatal period with severe and chronic metabolic acidosis, 5-oxoprolinuria, and mild/moderate hemolytic anemia

Symptoms need context, and treatment decisions should account for diagnosis, medications, labs, infection risk, nutritional status, and overall health

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Therefore, cortistatin-based therapies emerge as attractive alternatives for treating chronic neuropathic pain of different etiologies

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