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In a recent review of smoking-related mortality in developed countries (Peto et al, 2003), it has been estimated that during the year 2000 in the 15 countries, then members of the European Union, there were 172 000 smoking-attributed male deaths at ages 3569, comprising 29% of all male deaths in this age range, while for all ages the corresponding figures were 398 000 and 22%

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Part of its rationale was that meta-analyses are observational in nature and can at times be confounding

Skin patches, gums, lozenges, and nasal sprays can all deliver nicotine without the toxic tars and gases found in cigarette smoke

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