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Furthermore, downregulation of ROS generation in stem cells is achieved through a reduced dependence on oxidative phosphorylation [121, 122]

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Mating in ragworms, Platynereis dumerilii , only occurs after the individuals have undergone a metamorphosis into a reproductive form that has only one purposethe release of gametes after which it dies ( nuptial danc e that culminates in the release of gametes, and spawn in moonlight-controlled mass events

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Such a setup would precisely delineate the NSC-derived paracrine factors (e.g., BDNF, VEGF [18, 32], TGF-) responsible for suppressing microglial activation and promoting an anti-inflammatory phenotype, independently of in vivo complexities