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Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health

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Long-term administration in mice inhibited development of leukemia by 6-fold and reduced total spontaneous tumor incidence, with no increase in cancer risk despite telomerase activationaddressing theoretical concerns about uncontrolled proliferation

Conversely, p53-mutant MDA-MB231 breast tumor cells showed a high apoptosis rate exceeding 30%, along with a low percentage of cells undergoing senescence [94]