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Other important micronutrients: In addition to the above, various vitamins and trace elements are also considered in orthomolecular therapy for lipoedema: Vitamin B12: Many lipoedema patients complain of pain with a neuropathic component (discomfort, pressure pain)

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doi: 10.3389/fphar.2022.871392 86 GrossMIDemoSDDennisonJBChenLChernov-RoganTGoyalBet al

Therefore, it is necessary to further explore the precise metformin doses required to change the AMP/ATP ratio and activate AMPK, in order to fully understand the effect of metformin on complex I (Table 4)

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