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1 Introduction Diabetic kidney disease (DKD) is one of the microvascular complications of diabetes mellitus (DM), imposing a huge economic burden on individuals and public health systems ( 2 Renal tubular changes in DKD Almost 90% of the renal parenchyma consists of renal tubules and tubulointerstitial tissue

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

2021 doi: 10.1111/bph.15615

Inflammation-driven vascular changes, including swelling, decreased oxygen transport, and microthrombi, restrict nutrient and hormone precursor availability

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Benton CB, Al Rawi A, Wang F, Zhang J, Jorgensen J, Mu H, Schober W, Alaniz Z, Gumbs C, Futreal A, Garcia-Manero G, Kantarjian H, Navin, N, Konopleva M, Andreeff, M