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Low B12 in the body is also associated with having poor energy, frequent fatigue, and weakness

People with these genetic changes might need different doses to get the best results

Persistently low B12 levels can cause pernicious anemia, stomach problems or nerve damage

Anyone with significant medical conditions, anyone pregnant or breastfeeding, and anyone on multiple medications needs a careful review first not because problems are expected, but because limited human data means we don't assume

In most other countries the maximum time between injections is two months

These approaches are mechanistically complementary one adds substrate, the other prevents its degradation