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[3] It plays an essential role in the nervous system by supporting myelin synthesis and is critical for the maturation of red blood cells in the bone marrow

Knockdown of NNMT in adipocytes was associated with increased NAD+ levels and altered expression of genes involved in energy expenditure, providing the rationale for pharmacological NNMT inhibition [2]

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Because it works at the cellular level restoring NAD+ so fat cells become metabolically active again changes tend to be gradual and build over weeks, and they show up best alongside solid nutrition, training, and the rest of your plan

Suzuki M, Tamura T, Shimomura Y

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