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We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion

Singh et al., 2008

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Results showed dose-dependent weight loss: the 0.25mg dose produced 4.5% additional weight loss beyond diet and placebo, the 0.5mg dose achieved 9.2% weight loss, and the 1.0mg dose resulted in 10.6% weight lossrepresenting approximately twice the efficacy of other approved obesity drugs available at that time

The cycling protocols commonly recommended are partly based on this theoretical concern, though actual tolerance development has not been documented

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