But don't just take my word for it
Serum B12, and potentially methylmalonic acid (MMA) and homocysteine, give your clinician the data to determine whether B12 is a contributing factor or whether the mood symptoms are being driven by something else entirely
Dress comfortably
Methyl donors are needed to make a neurotransmitter called serotonin, which controls mood
Given that GHK-Cu is a naturally occurring molecule present in human plasma, concerns about long-term topical use seem largely theoretical
In a transcriptomic analysis of pre-menopausal and peri-menopausal stromal fibroblasts, over 1,000 genes were found to be differentially expressed between these two age groups ( PR ) and estrogen receptor beta ( ESR2 ), and upregulation of estrogen receptor alpha ( ESR1 ) in the younger cohort ( In vitro studies have demonstrated that hypoxia-induced endometrial stromal cell senescence leads to impaired decidualization as evidenced by incomplete morphological transformation and reduced expression of decidualization markers IGFBP1 and PRL ( in vitro decidualization of HESCs, confirmed by upregulated expression of PRL , IGFBP1 and FOXO1 , resulted in an increase in expression of senescence markers p21 and p53 , suggesting that decidualization may promote cellular senescence (Kusama et al., 2021)
