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In addition, both AICAR and RSVa SIRT1 activatorhave demonstrated efficacy in promoting mitochondrial adaptation and biogenesis, thereby reducing TEC injury and renal fibrosis in preclinical studies (Hong et al., 2017

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All treatments were administered in a volume of 100 L orally by gavage, 24 h before and immediately before CLP induction (time 0)

The membranes were hybridized and exposed to phosphor screens for imaging

Controlled dosing is important for long-term use