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ACSL4 acylates AA, LPCAT3 catalyzes the acylated AA into membrane PLs, and then lipoxygenases (LOXs) catalyze PUFA PLs, producing native lipid peroxidation (Figure 1)

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Functioning of an arteriovenous fistula requires heme oxygenase-2

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It has undergone clinical studies and was found to increase blood glutathione levels while supporting the immune system

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