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However, glutathione levels may be depleted or significantly reduced if the body's oxidative stress is very high and plasma antioxidant capacity is clearly reduced

Noutoshi Y, Ito T, Seki M, Nakashita H, Yoshida S, Marco Y, Shirasu K, Shinozaki K

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These genes were reported to contribute to the susceptibility to ferroptosis, suggest genetic variations, particularly single nucleotide polymorphisms, in these genes may contribute to the pathogenetic susceptibility of CKD [37]