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4 Classification of melasma Melasma can be clinically classified as centrofacial (with the highest incidence rate), malar and mandibular skin patches

This could be due to several factors such as curvature of the cerebellum, shape of the overlying bone and sinuses, tissue density, or its relatively weak mechanical attachment to the rest of the brain via three pairs of fiber bundles, which all could affect the proper anchoring of electrodes to the targeted region

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