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Rueda-Ruzafa et al

It's not a congenital immunodeficiency, but it really becomes a toxin-mediated immune deficiency a reflection of all the toxicity that is modulating their immune response in a really profound and significant way, which frankly terrifies me for these kids

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Mechanistically, kefiran (KE) and kefir exo-polysaccharides (KEPS), as well as KPs, inhibit key inflammatory signaling pathways including NF-B, p-MAPK, p-IkB, pp38, and p-JNK, thereby reducing epithelial cell activation, synovitis, macrophage-mediated inflammation, and cytokine overproduction in systemic and localized inflammatory conditions (Chuang et al., 2023

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Selank, for example, demonstrates anxiolytic effects comparable to benzodiazepines in clinical studies without the sedation, amnesia, or dependence that make benzodiazepines problematic for long-term use