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However, because the plasma membrane presents a barrier to most charged molecules, current approaches to MGD discovery exclude the large fraction of E3 ligases that bind charged clients

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On January 26, 2024, the ICJ ordered Israel to take immediate and effective measures to enable the provision of urgently needed basic services and humanitarian assistancein the Gaza Strip. Despite this binding order, Israel continued to restrict or block aid

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Popova et al., 2015)