The cellular availability of Cys and bidirectional flux of cellular thiols across the plasmalemma may influence the interaction of the GST tag
Jandric I, Vrcic H, Jandric Balen M, et al
The use of small molecules that alter the levels of ROS such as -phenethyl isothiocyanate (PEITC), buthionine sulphoximine, curcumin, or 2-cyano-3,12-dioxooleana-1,9-diene-28-oic acid (CDDO) derivatives, has been suggested for the treatment of cancer by promoting ROS generation and GSH depletion in cancer cells (Schumacker, 2006
Due to the dysregulation of GLS in a variety of cancers, GLS inhibition has attracted attention
Peptides are fragile and notoriously hard to deliver into the skin
Repeat courses can be run if a new injury occurs or symptoms recur after the initial course