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It's a clear-eyed "we have strong signals and not yet the definitive proof." I'd rather hand you that than a fairy tale

The presence of the specialized tripeptide KPV allows researchers to monitor the competitive downregulation of nuclear factor kappa B (NF-kB) and trace the inhibition of pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) within inflamed intestinal or cutaneous tissues

Taking certain medications regularly can also cause this

The majority of the published literature examines each compound independently, and the synergy hypothesis, while mechanistically well-supported, has not yet been the subject of large-scale controlled studies

Shots support that foundation

Maintains some benefit while halving annual cost