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This barrier severely restricts drug delivery and prevents potentially effective central nervous system treatments from being used clinically [112]

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Following subcutaneous injection, the peptide enters systemic circulation with bioavailability of 14-19% in rats, while intramuscular administration achieves 45-51% bioavailability in beagle dogs, indicating both route-dependent and species-dependent absorption characteristics

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Although the mechanisms of their action require clarification some were recognized as inhibitors of H