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Subsequently, Chang et al

R 11 is H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, C 2 -C 7 heterocycloalkyl, C 6 -C 10 aryl, C 3 -C 9 heteroaryl, C 1 -C 6 alkylC 3 -C 6 cycloalkyl, C 1 -C 6 alkylC 6 -C m aryl, or C 1 -C 6 alkylC 3 -C 9 heteroaryl;R 12 is H, C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, C 3 -C 6 cycloalkyl, C 2 -C 7 heterocycloalkyl, C 6 -C 10 aryl, C 3 -C 9 heteroaryl, C 1 -C 6 alkylC 3 -C 6 cycloalkyl, C 1 -C 6 alkylC 6 -C 10 aryl, or C 1 -C 6 alkylC 3 -C 9 heteroaryl

104 In clinical practice, immunohistochemical results are often used to define the four subtypes, namely luminal A, luminal B, HER2enriched, and TNBC

10.1007/978-3-030-44599-7_7 [DOI] [Google Scholar] Behrendt, R

In the male, AOXs may enhance fertility through preserving sperm DNA integrity and mitochondrial transport (70)

However, survodutide has carved out a distinct position in MASH treatment with FDA Breakthrough Therapy Designation and dedicated Phase 3 MASH trials