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GSH synthesis and consumption The synthesis of GSH relies on cysteine as the starting material, and cellular resistance to lipid oxidation depends on intracellular cysteine levels, primarily produced by the system Xc and transsulfuration pathways

Well-designed studies are still needed to clarify its role in the management of patients with SCD and to assess the safety of this approach (van Zuuren and Fedorowicz, 2015)

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doi: 10.1146/annurev.nu.07.070187.001033 96

Oxidative Med Cell Longevity 2015 (1):170309 Suzuki T, Motohashi H, Yamamoto M (2013) Toward clinical application of the Keap1Nrf2 pathway