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While these trials showed the benefits of transfusions in stroke prevention, their role in treating SCD acute chest syndrome is less clear ( Currently, the only two curative treatments of SCD are hematopoietic stem cell transplantation (HSCT) and Lyfgenia, another recently FDA-approved gene therapy that modifies patients stem cells to produce normal hemoglobin (Two Gene Therapies for Sickle Cell Disease, 2024) (Figure 1)

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